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- W2375551441 abstract "Objective:To study the bioequivalence of Hydrochloride Tablets in healthy volunteers.Methods:In a randomized two-way crossover design.20mg single dose tablets A and B were respectively given to 10 male healthy volunteers.A rapid and sensitive HPLC assay was modified for determination of the drug levels in plasma.Results:The t max of tablets A and B were (1 72±0 39)h and (1 65±0 55)h,the C max (613±121 7)ng/ml and (597±119 8)ng/ml,(11 5±2 7)h and (12 0±2 9)h,AUC 0～24 (2 855 1±528 3)h·ng/ml and (3 016 4±702 8)h·ng/ml,respectively,and t1/2(11 5±2 7)h and (12 0±2 9)h.The mean relative bioavailability of the tablets B vs A was (100 2±7 4)%.There is no significant difference between the two products.Conclution:These two products are bioequivalent." @default.
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- W2375551441 date "2002-01-01" @default.
- W2375551441 modified "2023-09-23" @default.
- W2375551441 title "STUDY ON BIOEQUIVALENCE OF CETIRIZINE HYDROCHLORIDE TABLETS" @default.
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