Matches in SemOpenAlex for { <https://semopenalex.org/work/W2375553742> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2375553742 abstract "ObjectiveTo investigate the effect of NF-κB on the differentiation and maturation of mu rine bone marrow-derived dendritic cells (DC) in vitro.MethodsThe activity of NF-κB in dendritic cells was blocked by oligodeoxyribonucleot ide Decoys (ODN Decoys) containing two special binding sites for NF-κB. Morpho logical changes of DS were observed. The expression of assistant molecules on th e cell surface was detected by using flow cytometer, and the stimulating activit y of allogeneic T lymphocyte proliferative response was determined in culture mu rine DC. The effect of NF-κB on the maturation and immunobiological activity o f murine DC was studied.ResultsNF-κB ODN Decoys were efficiently incorporated by DC, markedly suppressed the maturation of DC, the expression of assistant costimulatory molecules (CD80, CD8 6 and CD40) on the surface of DC and the secretion of IL-12, blocked the develo pment of DC and this blocked function was not reversed by lipopolysaccharide (LP S). In mixed lymphocyte reactions, DC treated with NF-κB ODN Decoys could indu ce allogeneic T cells hyphoresponsiveness, and this was associated with the inhi bition of Th1-type cytokines (IL-2 and IFN-γ) production.ConclusionsNF-κ B is a key gene to the development and maturation of DC. Specific interference w ith NF-κB in DC using ODN Decoys approaches could offer a novel strategy for i nducing and generating tolerogeneic immature DC and provide a promising means to induce transplant immune tolerance." @default.
- W2375553742 created "2016-06-24" @default.
- W2375553742 creator A5002492841 @default.
- W2375553742 date "2004-01-01" @default.
- W2375553742 modified "2023-09-24" @default.
- W2375553742 title "Effect of NF-κB Decoys on development and maturation of dendritic cells and in itiation of Tcells immune response in vitro" @default.
- W2375553742 hasPublicationYear "2004" @default.
- W2375553742 type Work @default.
- W2375553742 sameAs 2375553742 @default.
- W2375553742 citedByCount "0" @default.
- W2375553742 crossrefType "journal-article" @default.
- W2375553742 hasAuthorship W2375553742A5002492841 @default.
- W2375553742 hasConcept C153911025 @default.
- W2375553742 hasConcept C154317977 @default.
- W2375553742 hasConcept C167672396 @default.
- W2375553742 hasConcept C185592680 @default.
- W2375553742 hasConcept C202751555 @default.
- W2375553742 hasConcept C203014093 @default.
- W2375553742 hasConcept C2776090121 @default.
- W2375553742 hasConcept C2778170410 @default.
- W2375553742 hasConcept C2778297628 @default.
- W2375553742 hasConcept C2778754761 @default.
- W2375553742 hasConcept C2781101188 @default.
- W2375553742 hasConcept C39347974 @default.
- W2375553742 hasConcept C55493867 @default.
- W2375553742 hasConcept C86803240 @default.
- W2375553742 hasConcept C8891405 @default.
- W2375553742 hasConcept C95444343 @default.
- W2375553742 hasConceptScore W2375553742C153911025 @default.
- W2375553742 hasConceptScore W2375553742C154317977 @default.
- W2375553742 hasConceptScore W2375553742C167672396 @default.
- W2375553742 hasConceptScore W2375553742C185592680 @default.
- W2375553742 hasConceptScore W2375553742C202751555 @default.
- W2375553742 hasConceptScore W2375553742C203014093 @default.
- W2375553742 hasConceptScore W2375553742C2776090121 @default.
- W2375553742 hasConceptScore W2375553742C2778170410 @default.
- W2375553742 hasConceptScore W2375553742C2778297628 @default.
- W2375553742 hasConceptScore W2375553742C2778754761 @default.
- W2375553742 hasConceptScore W2375553742C2781101188 @default.
- W2375553742 hasConceptScore W2375553742C39347974 @default.
- W2375553742 hasConceptScore W2375553742C55493867 @default.
- W2375553742 hasConceptScore W2375553742C86803240 @default.
- W2375553742 hasConceptScore W2375553742C8891405 @default.
- W2375553742 hasConceptScore W2375553742C95444343 @default.
- W2375553742 hasLocation W23755537421 @default.
- W2375553742 hasOpenAccess W2375553742 @default.
- W2375553742 hasPrimaryLocation W23755537421 @default.
- W2375553742 hasRelatedWork W1484473284 @default.
- W2375553742 hasRelatedWork W1518118068 @default.
- W2375553742 hasRelatedWork W1567741823 @default.
- W2375553742 hasRelatedWork W1570594698 @default.
- W2375553742 hasRelatedWork W1577227574 @default.
- W2375553742 hasRelatedWork W1658073345 @default.
- W2375553742 hasRelatedWork W1975130840 @default.
- W2375553742 hasRelatedWork W1978078815 @default.
- W2375553742 hasRelatedWork W1999160874 @default.
- W2375553742 hasRelatedWork W2042433404 @default.
- W2375553742 hasRelatedWork W2051436104 @default.
- W2375553742 hasRelatedWork W2074216658 @default.
- W2375553742 hasRelatedWork W2134779076 @default.
- W2375553742 hasRelatedWork W2135668977 @default.
- W2375553742 hasRelatedWork W2159532100 @default.
- W2375553742 hasRelatedWork W2171083693 @default.
- W2375553742 hasRelatedWork W2171928291 @default.
- W2375553742 hasRelatedWork W2385825001 @default.
- W2375553742 hasRelatedWork W2560766642 @default.
- W2375553742 hasRelatedWork W266774029 @default.
- W2375553742 isParatext "false" @default.
- W2375553742 isRetracted "false" @default.
- W2375553742 magId "2375553742" @default.
- W2375553742 workType "article" @default.