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- W2375581296 abstract "Objective To study the effect of dimethylarsinic acid( DMAV) on NF-κB signaling pathway in bladder epithelial cells of rats. Methods Sixty female Wistar rats,were randomly divided into control group,100ppm( DMAV) exposed group and 200 ppm DMAVexposed group,after 10 weeks exposure by drinking water infected 10 weeks to be put to death the rats were killed. The Real Time PCR methodwas used for measuring the expression of IKKα and p65 mRNA in bladder epithelium from urine,and the immunohistochemical method was used for observe the expression of IKKα,p65 proteins in bladder epithelium from urine. Results The expression level of IKKα mRNA in rat bladder epithelial cells was significantly increased in100 ppm DMAVgroup( P 0. 05),but p65 mRNA expression had no significant change,additionally,the IKKα protein expression and nuclear p65 positive rate were also rised in this group than that of control group( P 0. 01); While in 200 ppm DMAVgroup,except the slight increase of nuclear p65 positive rate( P 0. 05),there was no other significant change( P 0. 05). Conclusion low dosage of DMAVmay activate the NF-κB signal pathway in bladder epithelial cells of rat." @default.
- W2375581296 created "2016-06-24" @default.
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- W2375581296 date "2015-01-01" @default.
- W2375581296 modified "2023-09-23" @default.
- W2375581296 title "Effects of dimethylarsinic acid on expression levels of IKKα and p65 in bladder epithelial cells of rats" @default.
- W2375581296 hasPublicationYear "2015" @default.
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