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- W2375593570 abstract "Objective:To detect the immunog enicity of the bioscaffold used in building tissue engineered blood vessels.Methods:The carotid arteries of pigs were cut into 2 cm long segme nts and were randomly divided into 3 groups:the control group,the decellulariz ed group,and the decellularized/base treated group.Major histocompatibility c omplex class Ⅰ(MHCⅠ),which was highly expressed in vascular mural cells,was ch osen t o evaluate the antigenic changes of the vessels before and after decellularized treatment.The staining results were analyzed with image analysis system.Results:MHCⅠ was highly expressed in the control group,while after treatments its detectable rate dropped significantly.The ratio of positive gra nular area to the visual area was (24.09±6.09)% in the control group,(6.71±2.1 8 )% in the decellularized group and (1.62±0.76)% in the decellularized/base tre ated group.The differences among groups were significant ( P 0.01).C onclusion:MHCⅠ immunohistochemical staining can serve as a valuable m ethod to detect the antigenicity of the vascular bioscaffold." @default.
- W2375593570 created "2016-06-24" @default.
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- W2375593570 date "2004-01-01" @default.
- W2375593570 modified "2023-09-25" @default.
- W2375593570 title "Immunohistochemical observation of major histocompatibility complex class I ant igenicity in decellularized scaffolds of tissue engineered blood vessels" @default.
- W2375593570 hasPublicationYear "2004" @default.
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