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- W2375598343 abstract "To investigate effects of δ1 opioid receptor agonist 2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aα-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide(TAN—67) on myocardial hypoxic-ischemic injury in rats with hemorrhagic shock,twenty-four male SD rats were randomly divided into 3 groups(n=8 each):sham group,control group and TAN—67 group.The animals in control and TAN—67 groups were exsanguinated till MAP decreased to 40 mmHg.Rats were resuscitated with shed blood after administered to normal saline or TAN—67 at the end of shock period.Mean arterial pressure(MAP),cardiac function(LVP,±dp/dtmax) were recorded after resuscitation for 2 h.Morphological changes in myocardium were observed by electron microscope.FlaMeng' semi-quantitative analysis of mitochondria was used to analyze electron microscope specimens.Higher scores indicated more serious damage.After hemorrhagic shock and resuscitation,hemodynamics gradually decreased in control group.While hemodynamics in TAN-67 group are significantly increased compared with control group.Myocardial injury is less severe than that in control group.TAN—67 could improve the hemodynamics and reduce myocardial injury during the course of hemorrhagic shock." @default.
- W2375598343 created "2016-06-24" @default.
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- W2375598343 date "2009-01-01" @default.
- W2375598343 modified "2023-09-24" @default.
- W2375598343 title "Effects of δ_1 Opioid Receptor Agonist on Myocardial Injury Induced by Hemorrhagic Shock in Rats" @default.
- W2375598343 hasPublicationYear "2009" @default.
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