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- W2375603485 abstract "Objective To explore the effects of tumor volume on long-time efficacy of stage Ⅲ non-small cell lung cancer(NSCLC) after three dimensional conformal radiotherapy(3D-CRT). Methods From August2000 to December 2004,72 patients,29 cases were in ⅢA and 43 cases in ⅢB stage. 32 cases were treated with radiotherapy alone,while 40 cases with concurrent or sequential radiotherapy and chemotherapy. 28cases were treated with conventional radiotherapy(CRT) and later-course 3D-CRT,while 44 cases with3D-CRT. The median equivalent dose was 6 625 cGy(5 000-7 800 cGy). DVH was used for assessing GTV,CTV and PTV.Standard of RTOG Radiation was used for evaluating induced esophagitis and pneumonitis.Results 69 cases were followed up for 5 years and rate was 95.8%. After radiotherapy,there were 14 cases of CR,42 cases of PR,and 16 cases of SD. Overall survival rate and median survival time of 1 year,3 years,and 5 years was 45.8%,15.3%,10.5% and 10.2 months,respectively. All patients were divided into two groups according to GTV median(155 cm3). Only the incidence of grade 2 radiation induced pneumonitis in group of GTV155 cm3was higher than that in group of GTV≤155 cm3(P0.05),while there was no significant difference in gender,age,T,N,TNM,biologic equipotent dose,radiation style,chemotherapy and radiation esophagitis between two groups. Overall survival rate and median survival time of 1 year,3years and 5 years of patients with GTV≤155 cm3and 155 cm3were 61.1%,19.4%,16.2%,17 months and30.6%,11.1%,4.2%,9 months respectively(χ2=5.16,P=0.023). CTV and PTV were divided into two groups according to median,and there was significant difference in survival rate(P0.05). With univariate analysis of all prognosis,GTV,CTV,PTV,and immediate effect were related with prognostic survival(P0.05).Multivariable analysis indicated GTV and immediate effect were independent prognostic factors. Conclusion GTV was one important prognostic factor for stage III NSCLC after 3D-CRT,and immediate effect was another prognostic factor." @default.
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- W2375603485 date "2013-01-01" @default.
- W2375603485 modified "2023-09-24" @default.
- W2375603485 title "Effect on Long-time Survival for Different Tumor Volume in StageIIINon-small Cell Lung Cancer after Three Dimensional Conformal Radiotherapy" @default.
- W2375603485 hasPublicationYear "2013" @default.
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