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- W2375606899 abstract "Objective:To develop a new transdermal drug delivery system(solid lipid nanoparticles)for felodipine to improve its effect.Methods:Solid lipid nanoparticles were prepared by solvent-dispersion techique and were treated further by sonication.The release rate and permeation rate of felodipine were studied through excised rat skin in vitro.Results:Solid lipid nanoparticles containing felodipine were spherelike.The particle size was 50～150 nm;the drug entrapped efficiency was higher than 85%;the drug loading was not less than 7%.The release of felodipine from solid lipid nanoparticles followed the first grade model kinetics and the permeation rate of felodipine was remarkably higher in vitro than placebo.Conclusion:The formulation of solid lipid nanoparticles containing felodipine is reasonable.Solid lipid nanoparticles might be a suitable system for transdermal drug delivery." @default.
- W2375606899 created "2016-06-24" @default.
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- W2375606899 date "2008-01-01" @default.
- W2375606899 modified "2023-09-23" @default.
- W2375606899 title "Study on preparation and skin permeation of solid lipid nanoparticles containing felodipine" @default.
- W2375606899 hasPublicationYear "2008" @default.
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