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- W2375610441 abstract "Objective To explore the expressions of MUC1 and Cyclin D1 in the tissue of pancreatic cancer and its significance.Methods Immunohistochemical SP-staining method was performed to study semi-quantitatively the protein expressions of MUC1 and Cyclin D1 in 47 specimens of pancreatic cancer and 15 normal pancreatic tissue.Results The expressions of MUC1 and Cyclin D1 in pancreatic carcinomous tissue were 82.98%,68.09% respectively,which was significantly higher than that in normal pancreatic tissue(2.00%,0 respectively and P0.05).In addition,the expression of Cyclin D1 was correlated with that of MUC1,and the abnormal expressions of MUC1 and Cyclin D1 were all associated with lymphnode metastasis(P0.05).Furthermore,the expression of MUC1 was associated with the clinical stage and the expression of Cyclin D1 with the pathological differentiation(P0.05).Conclusion MUC1 and Cyclin D1 all participate in the oncogenesis and progression of pancreatic cancer that MUC1 is an ideal marker for the diagnosis and curative target of pancreatic cancer." @default.
- W2375610441 created "2016-06-24" @default.
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- W2375610441 date "2011-01-01" @default.
- W2375610441 modified "2023-09-24" @default.
- W2375610441 title "Expression and Clinical Significance of MUC1 and Cyclin D1 in Pancreatic Carcinoma" @default.
- W2375610441 hasPublicationYear "2011" @default.
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