Matches in SemOpenAlex for { <https://semopenalex.org/work/W2375617811> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2375617811 abstract "Objective To explore the relationship of transforming growth factor beta 1(TGF-β1) gene rs1800469 and interleukin 12B(IL-12B) rs3212227 polymorphisms with the susceptibility to hepatocellular carcinoma(HCC).Methods A hospital-based case-control study was conducted in 608 cases with HCC and 612 controls matched for age,sex,nationality,and residence in Guangxi Zhuang Autonomous Region.Genotypes of TGF-β1 gene rs1800469(-509 CT)and IL-12B gene rs3212227(3'UTR+1188AC) were determined by real-time polymerase chain reaction with TaqMan MGB probe.Results The C allele mutation frequencies of IL-12B rs3212227 in the control group and case group were 43.5% and 48.9%,with a significant difference between the two groups(P0.05).Compared with wild rs3212227 AA genotype,the IL-12B rs3212227 C allele(adjusted odds ratio=1.336,95% confidence interval:1.040-1.717) was a significant determinant factor for HCC.The IL-12B rs3212227 AC and CC genotype increased the risk of HCC(adjusted OR=1.271,95%CI:0.976-1.655;adjusted OR=1.515,95%CI:1.092-2.102,respectively).No significant association was observed between the CT genotype and the TT genotype of TGF-β1 rs1800469 compared with the CC genotype(adjusted OR=1.087,95%CI:0.852-1.386;adjusted OR=1.087,95%CI:0.766-1.542,respectively).The stratified analyses revealed that the AC+CC genotype of IL-12B rs3212227 significantly increased the risk of HCC among the female and the subjects aged less than 55 years(adjusted OR=2.036,95%CI:1.169-3.548;adjusted OR=1.529,95%CI:1.129-2.071,respectively).No interaction was observed between TGF-β1 polymorphisms and the risk factors including age,smoking,alcohol drinking,and hepatitis B virus infection for the development of HCC.Conclusion Our results suggest that IL-12B rs3212227 polymorphisms may have independent effects on the susceptibility to HCC in Guangxi population." @default.
- W2375617811 created "2016-06-24" @default.
- W2375617811 creator A5081788564 @default.
- W2375617811 date "2011-01-01" @default.
- W2375617811 modified "2023-09-28" @default.
- W2375617811 title "Polymorphism of TGF-β1 and IL-12B gene and risk of hepatocellular cancer in Guangxi——a case-control study" @default.
- W2375617811 hasPublicationYear "2011" @default.
- W2375617811 type Work @default.
- W2375617811 sameAs 2375617811 @default.
- W2375617811 citedByCount "1" @default.
- W2375617811 countsByYear W23756178112013 @default.
- W2375617811 crossrefType "journal-article" @default.
- W2375617811 hasAuthorship W2375617811A5081788564 @default.
- W2375617811 hasConcept C104317684 @default.
- W2375617811 hasConcept C118131993 @default.
- W2375617811 hasConcept C126322002 @default.
- W2375617811 hasConcept C135763542 @default.
- W2375617811 hasConcept C143998085 @default.
- W2375617811 hasConcept C156957248 @default.
- W2375617811 hasConcept C180754005 @default.
- W2375617811 hasConcept C2778019345 @default.
- W2375617811 hasConcept C44249647 @default.
- W2375617811 hasConcept C54355233 @default.
- W2375617811 hasConcept C71924100 @default.
- W2375617811 hasConcept C86803240 @default.
- W2375617811 hasConcept C90924648 @default.
- W2375617811 hasConceptScore W2375617811C104317684 @default.
- W2375617811 hasConceptScore W2375617811C118131993 @default.
- W2375617811 hasConceptScore W2375617811C126322002 @default.
- W2375617811 hasConceptScore W2375617811C135763542 @default.
- W2375617811 hasConceptScore W2375617811C143998085 @default.
- W2375617811 hasConceptScore W2375617811C156957248 @default.
- W2375617811 hasConceptScore W2375617811C180754005 @default.
- W2375617811 hasConceptScore W2375617811C2778019345 @default.
- W2375617811 hasConceptScore W2375617811C44249647 @default.
- W2375617811 hasConceptScore W2375617811C54355233 @default.
- W2375617811 hasConceptScore W2375617811C71924100 @default.
- W2375617811 hasConceptScore W2375617811C86803240 @default.
- W2375617811 hasConceptScore W2375617811C90924648 @default.
- W2375617811 hasLocation W23756178111 @default.
- W2375617811 hasOpenAccess W2375617811 @default.
- W2375617811 hasPrimaryLocation W23756178111 @default.
- W2375617811 hasRelatedWork W116785814 @default.
- W2375617811 hasRelatedWork W1489977196 @default.
- W2375617811 hasRelatedWork W1980442297 @default.
- W2375617811 hasRelatedWork W2005291921 @default.
- W2375617811 hasRelatedWork W2273795640 @default.
- W2375617811 hasRelatedWork W2397478032 @default.
- W2375617811 hasRelatedWork W2413798092 @default.
- W2375617811 hasRelatedWork W2417990225 @default.
- W2375617811 hasRelatedWork W2419045667 @default.
- W2375617811 hasRelatedWork W2469006844 @default.
- W2375617811 hasRelatedWork W2528829554 @default.
- W2375617811 hasRelatedWork W2600156057 @default.
- W2375617811 hasRelatedWork W2607187075 @default.
- W2375617811 hasRelatedWork W2803281928 @default.
- W2375617811 hasRelatedWork W2920463838 @default.
- W2375617811 hasRelatedWork W2962670618 @default.
- W2375617811 hasRelatedWork W3101240141 @default.
- W2375617811 hasRelatedWork W3135362669 @default.
- W2375617811 hasRelatedWork W3175655013 @default.
- W2375617811 hasRelatedWork W832904340 @default.
- W2375617811 isParatext "false" @default.
- W2375617811 isRetracted "false" @default.
- W2375617811 magId "2375617811" @default.
- W2375617811 workType "article" @default.