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- W2375648003 abstract "AIM: To examine the influence of artificial cold exposure (ACE) on cerebrovascular responses to receptor-dependent and receptor-independent vasoconstrictors in renovascular hypertensive rat(RHR) and normal SD rat. METHODS: Twenty-four rats were randomly divided into 4 groups: RHR, RHT+ACE, SD and SD+ACE (n=6/group). RHR(SBP200 mmHg) was reproduced by two-kidney and two-clip(2k2c) way. Segments of the middle cerebral artery (MCA) from the 4 groups were mounted in Multi Myograph System for measurement of isometric contractions and cumulative concentration-dependent contraction to endothelin-1, U46619, phenylephrine, and extracellular K+ in normal Kreb's solution. RESULTS: There was no significant difference in vasoconstriction induced by phenylephrine, thromboxane A2 analog U-46619, endothelin-1 or high K+ in MCA between RHR and RHR+ACE. However, the constrictions to these constrictors were reduced in RHR and RHR+ACE compared with vessels from SD and SD+ACE. CONCLUSION: ACE results in a significant reduction in vasoconstrictive response to both receptor-dependent and-independent constrictors in MCA of SD rats, not RHR." @default.
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- W2375648003 date "2007-01-01" @default.
- W2375648003 modified "2023-09-25" @default.
- W2375648003 title "Different cerebrovascular responsiveness following artificial cold exposure in renovascular hypertensive rats and normal SD rats" @default.
- W2375648003 hasPublicationYear "2007" @default.
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