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- W2375680188 abstract "Objective To evaluate the effect of telmisartan,an angiotensinⅡAT1 receptor blocker(ARB),on metabolism and insulin sensitivity in elderly patients with type 2.diabetes mellitus and hypertension.Methods Subjects were divided into two groups according to the body mass index(BMI):the group of nonobese patients(n = 20 ) and the group of obese patients(n = 28 ). All the patients were administered telmisartan 80mg/d for 24 weeks.BMI,waist hip ratio(WHR),systolic blood pressure(SBP), diastolic blood pressure(DBP),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL -C),high density lipoprotein cholesterol(HDL - C),fasting plasma glucose(FPG),fasting insulin(FINS),HOMA - IR,and ANGⅡwere measured. Results In the basal state,SBP,DBP and levels of TG,TC,FPG,FINS,HOMA - IR and ANG II in the obese group were significantly higher than those in the nonobese group.Telmisartan treatment significantly reduced SBP,FINS,HOMA -IR,but increased ANGⅡlevels(all P0.05) in the nonobese group.Similarly,reductions in SBP,DBP,TG,TC,FPG,FINS,HOMA -IR,and ANGⅡlevels(all P0.05 ) were also seen in the obese group.Conclusions Telmisartan decreases blood pressure in elderly patients with type 2 diabetes mellitus and hypertension,especially patients with obesity,by improving the function of metabolism and insulin sensitivity." @default.
- W2375680188 created "2016-06-24" @default.
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- W2375680188 date "2011-01-01" @default.
- W2375680188 modified "2023-09-25" @default.
- W2375680188 title "Effects of telmisartan on metabolic changes and insulin sensitivity in elderly patients with type 2 diabetes mellitus and hypertension" @default.
- W2375680188 hasPublicationYear "2011" @default.
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