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- W2375701155 abstract "AD peptide vaccines were tested in clinical trials after a great success in transgenic mouse model of AD. Data indicates that and-Aβ antibodies play an important role in removing of brain amyloid depositions either in AD mice or in patients. To elicit appropriate and long lasting humoral response, we tried a different method of immunization,DNA vaccine. Sequences encoding one wild-type and another two mutants of Aβ genes were similarly cloned into pcDNA3.1hisA(-) for mammalian cell expression. BALB/c mice were immunized by intramuscular(i.m.) injections of 200 μg of plasmids per mouse every time without adjuvant. All animals received a total of 5-6 inoculations over a 3-4.5 month period(depending on different immunization protocols). Anti-Aβ antibody titers(IgG) were detected by enzyme-linked immunoadsordent assay. Strong humoral response were elicited in two of three groups, with average titers up to 1:11500 and 1:55600 to Ap. Average antibody titer of the third group also reached to 1:2640. More plasmids and frequent inoculations could activate first response or break the self-tolerance of mice. Anti-serums were also tested for their biological function to prevent cultured rat hippocampal neurons from the loxicily of Aβ fragmenls." @default.
- W2375701155 created "2016-06-24" @default.
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- W2375701155 date "2003-01-01" @default.
- W2375701155 modified "2023-09-25" @default.
- W2375701155 title "Induction of humoral immune response in BALB/c mice by plasmid DNA vaccines against Alzheimer's disease" @default.
- W2375701155 hasPublicationYear "2003" @default.
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