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- W2375707483 abstract "Objective To study the preventive effect of the lactulose on gut-originated endotoxemia in experimental acute liver injury.Methods The experimental model was produced by thioactamide(TAA).Fifty-eight rats were divided into 3 groups:TAA group(A),lactulose group(B)and normal control group(C).Animals in group A and B were respectively feed with normal saline or lactulose 2 ml,Bid×5 days.At the fourth day,these animals were given TAA 600 mg/kg sc to induce acute liver injury.After 48h of TAA injection,the endotoxin,tumor necrosis factor(TNF)and ALT in blood were measured.Also, the bacteria counting and endotoxin levels of intestinal content were measured.Results Compared with normal control,the levels of endotoxin,TNF and ALT in blood were significantly increased in group A(P0.01),bacteria counting of intestinal contents was evidently increased(P0.01);In addition, these was an increased level of endotoxin in the intestinal content(P0.01).However, the levels of endotoxin,TNF and ALT in blood,the bacteria counting and endotoxin levels of intestinal contents in group B were markedly lower than that in group A(P0.05).Conclusion Lactulose present preventive and therapeutic effects on gut-originated endotoxemia in experimental acute liver injury." @default.
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- W2375707483 date "2004-01-01" @default.
- W2375707483 modified "2023-09-23" @default.
- W2375707483 title "Preventive Effect of the Lactulose on Gut-Originated Endotoxemia due to Acute Liver Injury" @default.
- W2375707483 hasPublicationYear "2004" @default.
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