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- W2375735230 abstract "The single colonel composition of pituitary adenomas of human attests to the molecular basis of pituitary tumorigenesis. This review offers a specific overview of the involvement of alternation of tumor oncogenes and tumor suppressor genes (TSGs) in the pathogenesis of human pituitary adenomas. Mutations of gsp and H ras oncogenes genes and amplification of PKC have been identified in pituitary adenomas. Especially the mutation of gsp has been detected in 40% human GH secreting pituitary adenomas. The role of TSGs(tumor suppressor genes) including MEN 1, p53, Rb and p16 in pituitary adenoma formation and progression has yet be observed. Providing evidence proves that activation of oncogenes and inactivation of tumor suppressor genes seem to be at least one mechanism by which human pituitary adenomas origin and progress." @default.
- W2375735230 created "2016-06-24" @default.
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- W2375735230 date "2003-01-01" @default.
- W2375735230 modified "2023-09-25" @default.
- W2375735230 title "Gene mutation in pituitary adenomas of human" @default.
- W2375735230 hasPublicationYear "2003" @default.
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