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- W2375738233 abstract "Objective: To evaluate the long-term efficacy and safety of lamivudine(LAM) combined with thymosinα1(Tα1) in the treatment of the patients with chronic hepatitis B(CHB). Methods: 72 CHB patients aged 18 to 56 years (HBV-DNA and HBeAg,positive) were randomly divided by 1:1 proportion into two groups: 36 patients were given LAM alone(dose,100mg a day, orally,at least for one year)(i.e.LAM group); 36 patients LAM(usage dosage, the same as LAM group) plus Tα1(starting dose during the first 4 days of half a year cycle, 1.6mg a day, subcutaneously; after that,1.6mg,twice a week)(i.e.LAM + Tα1 group). Results: At one year, HBeAg seroconversion rate in LAM + Tα1 group was 44.4%(16/36), which was significantly higher than that in LAM group(5.6%,2/36)(P0.01). Through one-year follow-up after treatment, 58.3%(21/36) of ALT recovery rate in LAM + Tα1 group was obviously higher than that in LAM group(16.7%,6/36). Conclusion: The curative effect of LAM + Tα1 group, in the treatment of CHB, is superior to that of LAM group, which has little side effects." @default.
- W2375738233 created "2016-06-24" @default.
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- W2375738233 date "2006-01-01" @default.
- W2375738233 modified "2023-09-27" @default.
- W2375738233 title "Clinical Observation of Lamivudine combined with Thymosin α1 in Treatment of Patients with Chronic Hepatitis B" @default.
- W2375738233 hasPublicationYear "2006" @default.
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