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- W2375747502 abstract "Objective To investigate the effect of portal type Ⅳ collagenase administration on expression of α-SMA in cirrhotic liver induced by CCl4 subcutaneous injections in rabbits. Methods Male New Zealand rabbits were injected 0.23 mL of 50% CCl4/olive oil subcutaneously at gluteal region twice a week for 12 weeks to induce liver cirrhosis.The animals in control group administered same volumes of olive oil.After the portal delivery system(PDS) was established,33 rabbits which were successfully induced liver cirrhosis were randomly divided into 2 groups.The animals in group 1(n=16) were injected 1.5 mL of 0.1% type Ⅳ collagenase saline solution through PDS.The rabbits in group 2(n=17) received the same volume of 0.9% NaCl as controls.The injection was conducted 5 times a week and continued for 4 weeks.Another 30 animals which were injected with olive oil only were divided into group 3(n=15) and group 4(n=15),they underwent the same procedure.All animals were sacrificed after the last injection,and the livers were removed to detect the expression of α-SMA by immunohistochemistry.The integral optical density and area density were calculated by an imaging analysis system. Results The expression of α-SMA in the cirrhotic liver remarkedly increased.Portal administration of type Ⅳ collagenase significantly attenuated liver cirrhosis,but the expression of α-SMA increased in liver parenchyma. Conclusion Collagenase portal administration significantly increased the expression of αSMA in liver.This may attribute to the enhanced activation of hepatic stellate cells by collagenase treatment." @default.
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- W2375747502 date "2011-01-01" @default.
- W2375747502 modified "2023-09-23" @default.
- W2375747502 title "Effect of expression of α-SMA in liver cirrhosis by portal type IV collagenase administration" @default.
- W2375747502 hasPublicationYear "2011" @default.
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