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- W2375759790 abstract "Aim To study the pharmacokinetics of A771726,metabolite of leflunomide,in mice.Methods Caudal vein injection of single dose of A771726(4,12,36 mg·kg~(-1)),then calculate corresponding pharmacokinetic parameters based on the time process of blood drug concentration.Results The serum concentration-time curve of A771726 conformed to one compartment model of the first order absorption.The main pharmacokinetic parameters of A771726(4,12,36 mg·kg~(-1)) were t_(1/2ke)(h):(18.63 1.78),(31.07 7.33),(25.41 2.76);C_(0)(mg·L~(-1)):(19.92 1.20),(49.58 9.00),(182.14 22.98);AUC(mg·h~(-1)·L~(-1)):(533.99 41.49),(2173.88 440.21),(6621.97 584.25).Conclusion The metabolite of A771726 following caudal vein injection accords with the linear relation,and its serum concentration-time curve consists with the first-order kinetics of one-compartment model" @default.
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- W2375759790 date "2006-01-01" @default.
- W2375759790 modified "2023-09-28" @default.
- W2375759790 title "Pharmacokinetics of A771726 the metabolite of leflunomide in mice" @default.
- W2375759790 hasPublicationYear "2006" @default.
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