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- W2375766466 abstract "Objective: To study the effect of Breviscapin during ischemia-reperfusion injury of rat pancreas and assess the possible mechanism.Mothods: 45 SD rats were randomly divided into pseudoperation group(group A),ischima-reperfusion group(group B) and breviscapin group(group C).During the pancreas ischemia 30 minutes and reperfusion 0,6,12 hours,the level of tumor necrosis factor α(TNF-α),interleukin 1β(IL-1β) in the serum were determined by enzyme linked immunosorbent assay(ELISA).Expression of Survivin in pancreas celles were studied by immunohistochemical methods.Pancreas histopathology was observed respectively.Results: There were evident pathological changes in group B.The expression level of TNF-α,IL-1β in groups B,C was obviously higher than those in group A(P 0.05).But the level of TNF-α,IL-1β in groups C was obviously lower than those in group B(P 0.05).The expression level of Survivin in group C was higher than those in groups A,B at 6 h and 12 h of reperfusion(P 0.05).But there was no significant difference between group A and group B.Conclusions: Breviscapin can reduce the expression level of TNF-α and IL-1β during the pancreas ischemia and reperfusion,and can enhance the expression level of Survivin.It has protective effects on ischemia-reperfusion injury of rat pancreas." @default.
- W2375766466 created "2016-06-24" @default.
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- W2375766466 date "2013-01-01" @default.
- W2375766466 modified "2023-09-27" @default.
- W2375766466 title "Experimental Study on Possible Effect of Breviscapin in the Ischemia-reperfusion Injury of Rat Pancreas" @default.
- W2375766466 hasPublicationYear "2013" @default.
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