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- W2375771505 abstract "Objective To investigate the effect of glucocorticoid(GC) on the serum levels of interleukin-18(IL-18) and transforming growth factorβ-1(TGFβ-1) in new onset patients with myasthenia gravis(MG).Methods RandomLy selected 52 cases of patients with myasthenia gravis in our hospital for intervention group,according to age and gender matching 60 patients healthy controls.The serum level of IL-18 and TGFβ-1 were measured in 52 patients with MG before and after treatment with GC and in 60 health controls with ELISA.The absolute and relative scores of 52 patients with MG were rated by score system.Results The level of IL-18 and TGFβ-1 of patients with MG were significantly higher or lower than those of health group.The serum levels of IL-18 were significantly decreased and the levels of TGFβ-1 were increased after 2 months treatment with GC.There was not correlation between variation of IL-18 or TGFβ-1 concentrations and the relative scores of MG pre-and post-treatment.Conclusion GC can effectively regulate the function of cellular immunity by inhibiting the production of IL-18 and increasing secretion of TGFβ-1." @default.
- W2375771505 created "2016-06-24" @default.
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- W2375771505 date "2012-01-01" @default.
- W2375771505 modified "2023-09-23" @default.
- W2375771505 title "The effect of glucocorticoid on the serum levels of interleukin-18 and transforming growth factorβ-1 in new onset patients with myasthenia gravis" @default.
- W2375771505 hasPublicationYear "2012" @default.
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