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- W2375772018 abstract "Objective To investigate the expression and significance of adenosine 2A receptor(A2AR) in liver ischemia-reperfusion(I-R) injury in rats.Methods A2AR,MPO activity and proinflammatory cytokines MIP-2,ICAM-1,TNF-α in the liver were analyzed before ischemia,at 20 min after ischemia and at 0,1,3,6,12,18 and 24 h after reperfusion.Results The expression of A2AR gradually rose to the peak level at 12 h after reperfusion,which restorated to the normal levels at 24 h after reperfusion.The levels of tumor necrosis factor-α(TNF-α),macrophage inflammatory protein-2(MIP2) and intercellular adhesion molecule-1(ICAM-1) were gradually increased to the peak levels at 3 to 6 h after reperfusion,which were gradually reduced afterwards.So did the activity of myeloperoxidase(MPO).Conclusion The I-R-induced inflammatory response can induce the upregulation the A2AR expression,which may suppress the expression of inflammatory cytokines and tissue inflammatory injury." @default.
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- W2375772018 date "2010-01-01" @default.
- W2375772018 modified "2023-09-23" @default.
- W2375772018 title "Expression and significance of adenosine 2A receptor in liver ischemia-reperfusion injury in rats" @default.
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