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- W2375775087 abstract "[Objective]To investigate the effect of Kezhi capsule on hepatic expression of PPAR-γand IR in non-alcoholic steatohepatitis(NASH)rats.[Methods]High-fat diet was used to induce NASH in SD rats.Treatment groups were given Kezhi capsule and Rosiglitazone at the same time.Eight weeks later,blood samples were harvested to detect aspartate aminotransferase(AST),alanine transaminase(ALT),cholesterol total(CHO),low density lipoprotein(LDL),high density lipoprotein(HDL),and triglycerides(TG).Liver tissue samples were taken for hematoxylin-eosin(HE)staining and oil-red O staining.RT-PCR and western blot were used to observe the expression of PPAR-γ/IR mRNA and protein.[Results]Compared with the model group,the levels of serum TG,CHO,LDL,AST,and ALT in Kezhi capsule group were significantly decreased(P0.01).The results of HE and oil-red staining showed that Kezhi capsule lightened steatosis and inflammation.The RT-PCR and western blot results showed that the expression of PPAR-γ/IR mRNA and protein in the liver was remarkably increased in Kezhi capsule group compared with model group(P0.05).[Conclusion]Kezhi capsule has good preventive effect on non-alcoholic steatohepatitis rats.The mechanism might contribute to the up-regulation of expression of PPAR-γand IR to improve insulin resistance,then regulate the disorder of lipid metabolism and ameliorate hepatic function." @default.
- W2375775087 created "2016-06-24" @default.
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- W2375775087 date "2014-01-01" @default.
- W2375775087 modified "2023-09-25" @default.
- W2375775087 title "Experimental study of Kezhi capsule on PPAR-γand IR expression in non-alcoholic steatohepatitis rats" @default.
- W2375775087 hasPublicationYear "2014" @default.
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