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- W2375778075 abstract "Objective To study the role of α1,3-fucosyltransferaseⅦ(FUT7)in UVC-induced apoptosis of human hepatocarcinoma cell line SMMC-7721(7721). Methods The expression of FUT7 in both pcDNA3-FUT7 transfectant and mock pcDNA3 transfectant cells were detected by RT-PCR.The level of SLex was detected by flow cytometry.Apoptotic percentage was detected by DAPI staining.Survival percentage was detected by crystal violet staining.The levels of cleaved caspase3 and phosphorylation of p38MAPK,JNK1/2 and ERK1/2 were detected by Western blot. Results Overexpression of FUT7 attenuated UVC-induced apoptosis of 7721 and enhanced p38MAPK-signaling pathway.In addition,pretreatment with specific p38MAPK inhibitor reduced the anti-apoptotic effect of FUT7. Conclusions FUT7 functions as an anti-apoptotic molecule during UVC-induced apoptosis,at least in part,through enhancing p38MAPK-signaling pathway." @default.
- W2375778075 created "2016-06-24" @default.
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- W2375778075 date "2008-01-01" @default.
- W2375778075 modified "2023-09-24" @default.
- W2375778075 title "Overexpression of α1,3-fucosyltransferaseVII attenuates UVC-induced apoptosis of SMMC-7721 cells through enhancing p38MAPK-signaling pathway" @default.
- W2375778075 hasPublicationYear "2008" @default.
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