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- W2375792502 abstract "Objective: To establish a method for determination of Paracetamol,Caffeine,Aminopyrine in Paracetamol,aminophenazone phenacetin,caffeine and chlorphenamine maleate Granules by HPLC.Methods: The Kromasil C18 col-umn(4.6 mm×250 mm,5 μm) was used,a mixture of 1%-Acetic acid(adjust pH to 3.5 by triethylamine)-methanol-ace-tonitrile(65∶10∶25) as the mobile phase.The detection wavelength was at 273 nm,the flow rate was 1.0 ml/min.The temperature of the column was at 30℃.Results: The linear of range Paracetamol was at 12.3-123.2 μg/ml(r=0.999 6),the average re-covery was 98.65% with a RSD of 0.31%(n=3);the linear range of Caffeine was 2.44-24.42 μg/ml(r=0.999 8),the aver-age recovery was 99.15% with a RSD of 0.15%(n=3);the linear range of Aminopyrine was 8.23-82.34 μg/ml(r=0.999 9),the average recovery was 98.40% with a RSD of 0.39%(n=3).Conclusion: The method is simple,reliable and sensitive.This method can be used for the determination of Paracetamol,Caffeine,Aminopyrine in Paracetamol,aminophenazone phenacetin,caffeine and chlorphenamine maleate Granules." @default.
- W2375792502 created "2016-06-24" @default.
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- W2375792502 date "2010-01-01" @default.
- W2375792502 modified "2023-09-23" @default.
- W2375792502 title "Simultaneous determination of Paracetamol, Caffeine, Aminopyrine in Paracetamol, aminophenazone phenacetin, caffeine and chlorphenamine maleate Granules" @default.
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