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- W2375800188 abstract "Objective To study the mechanism of melatonin against rat liver fibrosis.Methods Rat liver fibrosis model was induced by carbon tetrachloride(CCl4),and meanwhile treated with melatonin i.p.at the dose of 10mg/kg body weight.The rats were killed at the end of 12th week,the expression of activated nuclear factor κB(NF-κB)subunit P65 in rats' liver was analyzed.The activated hepatic stellate cells(HSCs)labeled by α-smooth muscle actin(α-SMA)in the liver specimen were counted.The levels of alanine transaminase(ALT),asparagic acid transaminase(AST)and albumin(ALB)in serum were measured and the ratio of albumin against globulin(GLO)was calculated.Histological examination of rat liver was also measured.Results Melatonin inhibited the activation of NF-κB,the number of activated HSCs was also significantly decreased,the levels of ALT,AST were decreased,ALB and ALB/GLO were increased,hepatic inflammation and liver fibrosis were improved obviously(P0.05).Conclusion Melatonin inhibited the activation of NF-κB,ameliorated hepatic inflammation,and inhibited the activation of HSCs,improved rat liver fibrosis induced by CCl4." @default.
- W2375800188 created "2016-06-24" @default.
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- W2375800188 date "2010-01-01" @default.
- W2375800188 modified "2023-09-28" @default.
- W2375800188 title "A research on the mechanism of melatonin against rat liver fibrosis" @default.
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