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• W2375811632 abstract "Objective To explore the protective effect of EPO on chronic compressive injury of lumbar nerve root in rat. Methods 54 SD rats were randomly divided into NS control group,EPO epidural space administration group and EPO caudal vein injection group. The animals in each group separately were fed for 1,2 and4 weeks. There were 6 rats at each group of different time point. During the surgery the rats' left L5intervertebral foramen was inserted a steel hollow tube to form a stable compression on the nerve root while the steel tube was socketed PE pipe and led to the neck subcutaneous to get epidural space administration. After membrane operation the NS control group and EPO epidural space administration group were respectively injected NS and EPO via the PE pipe in epidural space. The EPO caudal vein injection group was injected EPO via caudal tail vein. After the administration the rats' behavior changes were observed. He staining was used to examine the pathological changes of spinal cord nerve cell. Immunohistochemical staining was used to detect the expression of caspase- 3 and BDNF. Using TUNEL method to label apoptotic cells and comparing the differences between different groups. Results After compression injury on the nerve root in rats,neurological damage behavior of the rats were changed. The neurobehavioral characteristics of recovery in the group at each time point treated with EPO was better than the control group( P 0. 05). The results of histological staining suggested that nerve cell in the spinal cord segment corresponding with nerve root compression from all of rats appears degeneration and apoptosis. At different time point,compared with NS control group,the number of apoptotic cells in the group treated with EPO was reduced( P 0. 05),the amount of caspase- 3 protein expression was significantly decreased( P 0. 05),the amount of BDNF protein expression was significantly increased( P 0. 05). There was no statistical difference between the group treated with EPO through epidural space and the group treated with administered with through vein. Conclusion Giving EPO can reduce the nerve function and pathological changes of nerve cells in the spinal cord and play a protective role." @default.
• W2375811632 created "2016-06-24" @default.
• W2375811632 creator A5029536385 @default.
• W2375811632 date "2013-01-01" @default.
• W2375811632 modified "2023-09-23" @default.
• W2375811632 title "The Protective Effect of EPO on Chronic Compressive Injury of Lumbar Nerve Root in Rats" @default.
• W2375811632 hasPublicationYear "2013" @default.
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