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- W2375821694 abstract "Objective:To explore the effect of ulinastatin on the level of NK cells of the patients after gynecologically laparoscopic surgery.Methods:Forty infertile patients undergoing selective laparoscopic surgery under general anesthesia were randomly divided into ulinastatin group and control group.The patients in ulinastatin group were treated with intravenous drip of ulinastatin(100 000 U) and normal saline(100 ml) within 15 minutes,then fentanyl,propofol,and cis-atracurium were injected to control respiration by endotracheal intubation,propofol and sevoflurane were applied during surgery to maintain anesthesia,the vital signs were sustained at normal levels,after surgery,the tubes were removed when the patients recovered spontaneous respiration and regained consciousness.The patients in control group were treated with intravenous drip of normal saline(100 ml),then anesthesia was performed,the other therapies were the same as those used in ulinastatin group.The venous blood samples were collected before surgery(T0),at the end of surgery(T1),at one day after surgery(T2),and at three days after surgery(T3),flow cytometry was used to detect the level of NK cells(CD16+56).Results:Compared with T0,the level of NK cells at T1 in control group had no obvious change,the levels of NK cells at T2 and T3 decreased significantly(P0.01);NK cells at T1 and T2 in ulinastatin group didn't change significantly,while at T3,the level of NK cells decreased(P0.05).The levels of NK cells at T2 and T3 in control group were significantly lower than those in ulinastatin group(P0.05).Conclusion:Compared with ulinastatin group,the level of NK cells in control group after surgery decreased significantly,which indicates that ulinastatin plays a certain protective role in immune function of patients undergoing gynecologically laparoscopic surgery." @default.
- W2375821694 created "2016-06-24" @default.
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- W2375821694 date "2012-01-01" @default.
- W2375821694 modified "2023-09-25" @default.
- W2375821694 title "Effect of ulinastatin on the level of NK cells of the patients after gynecologically laparoscopic surgery" @default.
- W2375821694 hasPublicationYear "2012" @default.
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