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- W2375822045 abstract "Objective To study the expression of clusterin protein and its relationship with multidrug resistance in human hepatocellular carcinoma(HCC).Methods In 41 HCC tissues,10 cirrhosis and 10 normal liver tissues,the expression of clusterin,P-glycoprotein(P-gp) and caspase-3 were detected by immunohistochemistry.Results Clusterin positive expression rate was 82.93%(34/41) in HCC,and negative or weak expression was detected in cirrhosis and normal liver tissue(P=0.00).The positive expression rate of clusterin in HCC was significantly correlated with Edmondson′s histological grade,but was no correlation with patients′age,sex,AFP,HBsAg and cirrhosis.The positive expression rate of caspase-3 and P-gp in HCC were 34.15%(14/41) and 70.73%(29/41),respectively.The negative relationship between the expression of clusterin and caspase-3 could be found with statistical significance(r=-0.36,P=0.02).The positive relationship between the expression of clusterin and P-gp could be found with statistical significance(r=0.42,P=0.006).Conclusions Clusterin over expression is significantly associated with multidrug resistance in HCC.It could be a potential target for treatment of HCC.The expression of clusterin is closely correlated to that of caspase-3 and they may play a synergic role in the course of anti-apoptosis." @default.
- W2375822045 created "2016-06-24" @default.
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- W2375822045 date "2007-01-01" @default.
- W2375822045 modified "2023-09-28" @default.
- W2375822045 title "RELATIONSHIP BETWEEN MULTIDRUG RESISTANCE AND EXPRESSION OF CLUSTERIN PROTEIN IN HUMAN HEPATOCELLULAR CARCINOMA" @default.
- W2375822045 hasPublicationYear "2007" @default.
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