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- W2375830964 abstract "Objective To ascertain the association of the neuropeptide Y receptor 2(NPY2R)polymorphisms with the efficacy of treatment for essential hypertensive patients with Benazepril.Methods 422 essential hypertensive subjects were selected counties of Anhui,China.The association between the blood pressure deduction and NPY2R polymorphism was analyzed with generalized estimating equation model.Results ①The NPY2R Ile312Ile(T/C)polymorphisms was associated with Diastolic Blood Pressure(DBP)decrease in response to a 16-day(16-day treatment:Crude:β±SE:2.07±1.29 mmHg,P=0.1092,adjusted:β±SE:2.48±1.20 mmHg,P=0.0386)and 13-day benazepril treatment(16-day treatment:Crude β±SE:4.37±2.46 mmHg,p=0.0094,adjusted β±SE:4.24±1.82 mmHg,P=0.0196).However,there was no association of the Systolic Blood Pressure(SBP)deduction with the NPY2R Ile312Ile(T/C)polymorphism.②There was no difference between the NPY2R genotypes of mutation and wild type before 13-day's treatment in DBP deduction,but in 14 and 16-day's treatment,the DBP deduction of mutation type was higher than the wild type.Conclusions The mutation of the NPY2R gene may increase the deduction of SBP in essential hypertension after 13-day bennzepril treatment.The NPY2R polymorphism is associated with time-efficacy in DBP deduction in response to benazepril treatment." @default.
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- W2375830964 date "2007-01-01" @default.
- W2375830964 modified "2023-09-25" @default.
- W2375830964 title "Neuropeptide Y 2 receptor polymorphism and systolic and diastolic blood pressure decreases after 16 days of benazepril treatment" @default.
- W2375830964 hasPublicationYear "2007" @default.
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