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- W2375841366 abstract "Objective Matrix metalloproteinases have been shown to be involved in the pathogenesis of tumor progression and metastasis in gastric carcinoma.In this study,we investigated the association between MMPs expressions and lymph node metastasis in early gastric carcinoma. Methods Thirtyfour LN positive and 80 LN negative pT1 tumors were immunohistochemically analyzed for MMP-2,MMP-7,and MMP-9 expression.The relation of MMPs expressions to LN metastasis was analyzed in the multivariete model. Results Immunohistochemistry showed significantly higher MMP-7 expression(P0.05) in LN positive tumors,whereas MMP-9 and MMP-2 in LN positive vs.57.5% in LN negative expression did not reach statistical significance. Multivariete analysis revealed that MMP-7 expression is an independent predictor of LN metastasis in EGCs, along with lymphatic invasion by tumor cells(P0.001). Conclusion Our study shows that MMP-7 expression is significantly associated with LN metastasis in EGC.MMP-7 expression can be used to predict LN status in EGCs in addition to other pathological parameters" @default.
- W2375841366 created "2016-06-24" @default.
- W2375841366 creator A5073020477 @default.
- W2375841366 date "2014-01-01" @default.
- W2375841366 modified "2023-09-23" @default.
- W2375841366 title "Matrix Metalloproteinase 7 Expression Predicts the Status of Lymph Node Metastasis in Early Gastric Carcinoma" @default.
- W2375841366 hasPublicationYear "2014" @default.
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