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- W2375841973 abstract "The mechanism of cytotoxicity by dehydrozingerone or zingerone in A549 human lung cancer cells was investigated.Cytotoxicity assay,DNA fragmentation assay and western blot analysis were performed.The results indicated that dehydrozingerone in the range of 40 μmol/L to 300 μmol/L inhibited A549 cell growth in a dose-dependent manner.In the presence of Cu(II),both dehydrozingerone and zingerone caused breakage of supercoiled plasmid pBR322 DNA.Dehydrozingerone had a high DNA cleavage activity.NAC reversed dehydrozingerone-induced A549 cell death.Up-regulation of CHOP contributed to dehydrozingerone-induced A549 cell death.The ER stress pathway involving CHOP was activated in dehydrozingerone-induced A549 cell death." @default.
- W2375841973 created "2016-06-24" @default.
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- W2375841973 date "2010-01-01" @default.
- W2375841973 modified "2023-09-23" @default.
- W2375841973 title "Studies on the Cytotoxicity of Dehydrozingerone in A549 Human Lung Cancer Cells" @default.
- W2375841973 hasPublicationYear "2010" @default.
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