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- W2375865570 abstract "Objective To analyze the resistance of patients with human immunodeficiency virus(HIV)-1 infection to the drugs for routine therapy in Jilin City,Jilin Province,China. Methods Blood samples of patients with HIV-1 infection, receiving antiviral therapy in Jilin City,were collected,from which RNAs were extracted for amplification of HIV-1 gene by nested PCR. The nucleotides of amplified products were sequenced by ABI 3100 sequencer,spliced by Sequencher 4. 9 software,then subjected to BLAST by using Bioedit software,and the results were compared with those of reference strains in Stanford HIV Drug Resistance Database,based on which the drug-resistant gene mutation and drug-resistance were analyzed. Results Drug-resistance was found in 27 of 49 patients,with a resistance rate of 55. 1%. Eight mutation sites were detected in the reverse transcriptase(RT)region,corresponding to resistances to nucleoside reverse transcriptase inhibitors(NRTIs)and non-nucleoside reverse transcriptase inhibitors(NNRTIs)respectively. Mutations of M184V were observed in 15,while M41L in 3 of the patients with resistances to NRTIs,causing 15 cases of resistance to Lamivudine(3TC) / Emdtricitabine(FTC) and 7 cases to Stavudine(D4T). Meanwhile,mutations of K103N were observed in 15,V106I in 8,Y181C in 6 and P225H in 4 of the patients with resistances to NNRTIs,causing 26 cases of resistance to Nevirapine(NVP),25 cases to Efavirenz(EFV) and 14 cases to Rilpivirine(RPV). However,only minor resistant mutations(A71V / T / I and L10I / V) were observed in protease region(PR),which caused no resistances to the corresponding drugs. Conclusion High drug-resistance rate was observed in patients with HIV-1 infection in Jilin City. The drug-resistance surveillance should be reinforced to modulate the individual therapeutic protocol for patients." @default.
- W2375865570 created "2016-06-24" @default.
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- W2375865570 date "2014-01-01" @default.
- W2375865570 modified "2023-09-25" @default.
- W2375865570 title "Drug-resistance of patients infected with human immunodeficiency virus-1 in Jilin City,Jilin Province,China" @default.
- W2375865570 hasPublicationYear "2014" @default.
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