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- W2375899335 abstract "Objective To explore the mechanisms of cytomegalovirus infection by investigating the changes of reactive oxygen species(ROS) and sequential changes of the vascular cell adhesion molecule-1(VCAM-1) and the receptors for advanced glycation end products(RAGE) in vascular endothelial cells with human cytomegalovirus(HCMV) infection.Methods Vascular endothelial cells were cultured and then infected by HCMV,then changes of reactive oxygen species were identified by confocal microscopy.Expressions of VCAM-1 and RAGE mRNA were determined by reverse transcriptase polymerase chain reaction.Results Fluorescence intensity was determined at a low level in the control group and was significantly increased in the HCMV group(P0.01).VCAM-1 mRNA was expressed at a low level at 0 hour,began to increase at 4 hours after HCMV infection and reached a peak at 8 hours.After 12 hours,it began to decrease and significantly decreased at 24 hours,but it was higher than that at 0 hour(P0.01).At 48 hours,the VCAM-1 mRNA level was close to that at 0 hour(P0.05).RAGE mRNA was expressed at a low level in the control group,began to increase 4 hours after HCMV infection,increased to a significant level at 12 hours,and reached a" @default.
- W2375899335 created "2016-06-24" @default.
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- W2375899335 date "2007-01-01" @default.
- W2375899335 modified "2023-09-26" @default.
- W2375899335 title "Mechanisms of vascular endothelial cell injury induced by human cytomegalovirus" @default.
- W2375899335 hasPublicationYear "2007" @default.
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