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- W2375911868 abstract "To research the immune protection induced by phosphoenolpyruvate carboxykinase(PEPCK) of Mycobacterium tuberculosis to mice,sixty BALB/c mice were divided into two groups.Each mouse in experimental group was injected with Emulsions comprising 10μg PEPCK antigen(Ag) in PBS and equal volumes of incomplete Freund's adjuvant(Difco).In control group,each mouse was only injected with equal volumes of incomplete Freund's adjuvant.All mice were immunized for three times with an interval of two weeks.Spleens and blood were taken 2 weeks after the final immunization.The amount of CD4+ and CD8+ T cells was assayed by flow cytometry.The response capability of lymphocytes was detected by MTT.At the same time cytokines such as IFN-γ,IL-12 and TNF-αwere detected by ELISA.The spleen of mouse in experiment group was much bigger than that of control group.The number of CD4+ T cells and the ratio of CD4+/CD8+ from experiment group were significantly higher than that of control group(P0.01).And the lymphocytes' responsion capability of mice in experiment group was stronger than that of control group.The amount of IFN-γ,IL-12 and TNF-α in PEPCK immunized mice was also higher than that of adjuvant group(P0.05).The titer of antibody in serum of PEPCK immunized mice got higher along with the immune times.The results showed that PEPCK could induce strong cellular and humoral immune responses,especially cellular responses and may be a good candidate for TB vaccine." @default.
- W2375911868 created "2016-06-24" @default.
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- W2375911868 date "2008-01-01" @default.
- W2375911868 modified "2023-09-26" @default.
- W2375911868 title "Celluar and humoral immune responses induced by phosphoenolpyruvate carboxykinase of Mycobacterium bovis BCG" @default.
- W2375911868 hasPublicationYear "2008" @default.
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