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- W2375917062 abstract "Objective To observe the effects of inhaled glucocorticoids on the two kinds of inflammatory bronchial asthma by analyzing sputum inflammatory phenotypes of the asthmatic patients with eosinophilic asthma(EA)or non-eosinophilic asthma(NEA).Methods 156cases of patients with asthma and 30cases of healthy control were enrolled in the study.Induced sputum technique was applied to collect sputum and for cytological analysis,the patients with asthma were devided into EA 86cases and NEA 70cases.The patients with asthma were inhaled with fluticasone 500μg·d-1 and placebo,4weeks later,the airway responsiveness and life quality score for asthma were observed.Results In NEA patients,the number of sputum eosinophils was significantly decreased compared with EA patients(0.5%±0.1%vs 9.9%±0.2%,P0.05),and the number of neutrophils was higher than that of EA patients (64.5% ± 8.5%vs 37.3% ± 7.5%,P0.05).After inhaled fluticasone 500μg·d-1 for 4weeks,in EA patients,compared with placebo group,the score of life quality in treatment group was significantly increased (P0.01),the methacholine PC20was increased group (P0.05),and FEV1 (%)was also increased(P0.05),the number of sputum eosinophils was significantly decreased (P0.01);whilecompared with placebo group,the above indexes in NEA patients had no significant difference (P0.05).The differences of methacholine PC20,sputum eosinophil numbers and the scores of life quality after treatment between EA group and NEA group were significant(P0.05).Conclusion NEA is characterized by the less number of airway eosinophils.After inhaled corticosteroid,the changes of methacholine PC20,sputum eosinophil numbers and the score of life quality in patients are not significant.But the characteristics of EA are opposite.So the patients with asthma can be treated targetely based on asthma phenotype according to sputum analysis." @default.
- W2375917062 created "2016-06-24" @default.
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- W2375917062 date "2010-01-01" @default.
- W2375917062 modified "2023-09-23" @default.
- W2375917062 title "Classification of bronchial asthma based on pathological features and their responses to corticosteroid" @default.
- W2375917062 hasPublicationYear "2010" @default.
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