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• W2375933902 endingPage "42" @default.
• W2375933902 startingPage "d27" @default.
• W2375933902 abstract "X-linked agammaglobulinemia (XLA) is a heritable immunodeficiency disorder that is caused by a differentiation block leading to almost complete absence of B lymphocytes and plasma cells. The affected protein is a cytoplasmic protein tyrosine kinase, Bruton's agammaglobulinemia tyrosine kinase (Btk). Btk along with Tec, Itk and Bmx belong to a distinct family of protein kinases. These proteins contain five regions; PH, TH, SH3, SH2 and kinase domains. Mutations causing XLA may affect any of these domains. About 200 unique mutations have been identified and are collected in a mutation database, BTKbase. Here, we describle, the structure, function, and interactions of the affected signaling molecules in atomic detail." @default.
• W2375933902 created "2016-06-24" @default.
• W2375933902 creator A5020878971 @default.
• W2375933902 creator A5036357426 @default.
• W2375933902 creator A5076316548 @default.
• W2375933902 date "1997-01-01" @default.
• W2375933902 modified "2023-10-11" @default.
• W2375933902 title "BTK the tyrosine kinase affected in X-linked agammaglobulinemia" @default.
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