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- W2375942007 abstract "Objective To investigate the regulation of ubiquitin-proteasome inhibitor MG132 on nuclear factor-κB(NF-κB)and its inhibitory signal protein IκB kinase degradation in earlier period diabetic retinopathy(DR),and explore the mechanism of ubiquitin-proteasome system in DR in rats.Methods Forty healthy adult male Wistar rats were divided into normal control group,DR placebo group,DR+low-MG132 treated group and DR+high-MG132 treated group randomly.In DR+low-MG132 treated group,the rats were intraperitoneally injected with 0.05 mg·kg-1 MG132 DMSO once a day,in DR+high-MG132 treated group were intraperitoneally injected with 0.10 mg·kg-1 MG132 DMSO once a day.The results of body masses and fasting blood glucose were detected,the expression of NF-κB and IκB in retina of every group were analyzed by immunohistochemistry.Results The expression of NF-κB p65 was obviously up-regulated in DR placebo group compared with control group,but the expression was down-regulated in DR+high-MG132 treated group compared with DR placebo group;The expression of IκBα was markedly down-regulated in DR placebo group compared with control group,but the expression was up-regulated in DR+high-MG132 treated group compared with DR placebo group,there were all significant differences(all P0.01).But there was no statistical difference on the expression of NF-κB p65 and IκBα between DR+low-MG132 treated group and DR placebo group(all P0.05).Conclusions Ubiquitin-proteasome system can influence the occurrence and development of DR by regulating NF-κB and IκBα expression.Application of ubiquitin-proteasome inhibitor MG132 can inhibit the ubiquitination of IκB degradation,and block the activation of NF-κB,which may play an early intervention role in DR." @default.
- W2375942007 created "2016-06-24" @default.
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- W2375942007 date "2010-01-01" @default.
- W2375942007 modified "2023-09-23" @default.
- W2375942007 title "Effect of MG132 on expression of NF-κB and IκB in early period diabetic retinopathy in rats" @default.
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