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- W2375944391 abstract "Objective:To explore the protection effects of total flavones from Taraxaci Herba(TF) on rats with viral myocarditis.Method:Fifty male BAIB/c mice were randomly divided into control group,model group,ribavirin group,TF low dose group(25 mg·kg-1),medium dose group(50mg·kg-1)and high dose group(100mg·kg-1).The mice in model group and therapy group were inoculated with CVB3.At 1st,3rd,7th,9th and 14th d,a part of the mice were killed,ardiomyocyte apoptosis was detected by the immunohistochemical technique and caspase-8 expression was detected by TUNEL staining method.Result:As compared with control group[(7th d(1.1±0.7)%;14th d(1.3±0.3)%],the level of ardiomyocyte apoptosis in model group[7th d(73.3±2.4)%;14th d(16.3±0.1)%]showed elevation.These indexes were obviously improved in treatment group,ribavirin group was[7th d(18.9±2.7)%;14th d(8.7±1.6)%]and those in TF medium,high dose groups were[(7th d(31.2±2.3)%;14th d(18.3±1.2),7th d(21.7±3.1);14th d(13.1±1.4)%]accordingly.The positive cell expression in model group was incressed significantly after inoculation it reached the peak at 7th d(27.2±1.17)%,and then declined,it was(9.2±1.17)% on the 14th d,which showed significantly elevation compared with control group[7th d(1.8±0.2)%;14th d(2.1±0.2)%],All of these indexes were obviously improved in treatment groups:ribavirin group was[7th d(10.12±1.15)%;14th d(2.12±1.15)%]and those in TF medium and high dose groups were [7th d(18.3±2.7);14th d(4.3±2.7)],[7th d(13.2±2.7)%;14th d(3.2±2.7)%]respectively.Conclution:TFD has a protective effect on ardiomyocyte in mice with viral myocarditis." @default.
- W2375944391 created "2016-06-24" @default.
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- W2375944391 date "2011-01-01" @default.
- W2375944391 modified "2023-09-24" @default.
- W2375944391 title "Effects of Total Flavones from Taraxaci Herba on Ardiomyocyte Apoptosis in Mice with Viral Myocarditis" @default.
- W2375944391 hasPublicationYear "2011" @default.
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