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- W2375963229 abstract "Objective:To establish the method of evaluating the skin penetration enhancer by chick embryo and chicken embryo chorioallantoic membrane.Methods:Irritancy of penetration enhancer was determinated by the chorioallantoic membrane test with trypan blue staining,the spectrophotometer was adopted to measure the absorptive amount of trypan blue at 595 nm.To add matrine solutions with different penetration enhancers into chick embryo air sac,then HPLC was used to assay the drug concentrations.Results:The discrepancy in irritations of various penetration enhancers(P0.05) could be observed.Linear relationships between concentration and irritation of azone solutions were obvious,r=0.9873.Significant differences of drug concentrations existed among groups of physiological saline,azone,propanediol and dimethyl sulfoxide(P0.05),The AUC0-240 min(μg·mL-1·min-1) were(4 000.55±192.57),(13 129.22 ±118.42),(8 340.58±367.42),(5 110.75±127.61),respectively.Conclusion:It was found that the 1% azone was effective and safe penetration for matrine.To estimate the skin penetration enhancer by this method was economical,feasible and worthy of further study." @default.
- W2375963229 created "2016-06-24" @default.
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- W2375963229 date "2010-01-01" @default.
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- W2375963229 title "Study and evaluation of skin penetration enhancer with chick embryos" @default.
- W2375963229 hasPublicationYear "2010" @default.
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