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- W2375981494 abstract "Objective To evaluate the clinical application value of analyzing karotypes of chorionic villus samples in early prenatal diagnosis. Methods The pregnant women with the indications of prenatal diagnosis were performed transabdominal chorionic villus sampling via the guidance of B-mode ultrasound. Cytogenetic cultures, chromosome preparation and karyotyping were performed. Results 451 cases were successfully cultured, with the success rate of cell culture of 97.41%. 136 cases were found with abnormal karotypes , the overall incidence of chromosomal abnormalities was 30.16% . 79 of 136 women diagnosed with chromosome number abnormalities , of which 55 cases were autosome trisomys . 23 cases were with sex chromosome number abnormalities and one case was triploid. 11 women were diagnosed with chromosome structural abnormality , 16 were mosaic and 30 were chromosome polymorphism. Abnormal karotype results were most likely found in indications of ultrasound screening abnormal fetus and of parents who carried structural abnormal chromosomes. Conclusion Early pregnancy villi cell chromosome examination combined ultrasound and serum screening can detect fetal chromosome aberrations at an early stage and make early intervention possible , which has great significance for minimizing the birth of chromosome abnormal children." @default.
- W2375981494 created "2016-06-24" @default.
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- W2375981494 date "2013-01-01" @default.
- W2375981494 modified "2023-09-26" @default.
- W2375981494 title "Analysis of 451 cases chromosome karyotype of chorionic villi samples at early pregnancy" @default.
- W2375981494 hasPublicationYear "2013" @default.
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