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- W2376002110 abstract "Objective:To establish an RP-HPLC method for the determination of taspine in rat blood plasma and to study its pharmacokinetics.Method:The blood plasma samples were isolated by liquid-liquid extraction and ana- lyzed by the RP-HPLC method,the chromatographic conditions used in this study were of Kromsil C_(18)ODS column (150 mm 4.6 mm,5μm)as analytical column,methanol-60 mmol·L~(-1)phosphate buffer-20 mmol·L~(-1)SDS (70:30)as mobile phase and at the flow-rate of 1.0 mL·min~(-1).The UV detection was set at 245 nm.Results:The calibration curve was linear in blood plasma over the concentration range of 15.63～903.7 ng·mL~(-1)(r= 0.994 0).Within-day and between-day precisions expressed as the relative standard deviation(RSD)were 3.8%～ 4.9% and 4.2%～7.6% respectively.Average recoveries added were(107.33±7.3)%～(97.30±4.8)%.The parameters were T_(max)=2.84 h,C_(max)=64.15 ng·mL~(-1),AUC=1214.98 ng·mL~(-1)·h,T_((1/2)(Ke))=10.96 h. Conclusion:The analytical method established in this study is stable and reliable,and can be used to measure the pharmacokinetics of taspine in rat.The experimental results show that taspine can be absorbed slowly,and slowly e- liminated after oral administration." @default.
- W2376002110 created "2016-06-24" @default.
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- W2376002110 date "2005-01-01" @default.
- W2376002110 modified "2023-09-23" @default.
- W2376002110 title "Pharmacokinetics of Taspine in Rats by RP-HPLC" @default.
- W2376002110 hasPublicationYear "2005" @default.
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