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- W2376014487 abstract "Objective To investigate the expression of non-classical HLA-Ⅰ(HLA-E)induced by interferon-gama(IFN-γ)in human hepatocarcinomal cells,and its effects on natural killer cells(NK)cytotoxicity to hepatocarcinomal cells.Methods Human hepatocarcinomal cells(BEL-7402)was in vitro consistently induced,respectively by different concentrations of IFN-γ for 72 h.The expression of HLA-E in each group was detested by immunocytochemistry,Western blot,semi-quantitative reverse transcriptase PCR and flow cytometry,and its effects on NK cytotoxicity to BEL-7402 cells was tested by NK killing rate.Results Compared with bland control group,HLA-E antigen,protein and mRNA were significantly increased in BEL-7402 cells induced by different concentrations of IFN-γ(100-1000 U/mL,P0.01),the HLA-E molecules on cell surface were increased correspondingly(P0.01).The HLA-E positive rate was higher and expression intensity stronger in high inducing concentration groups(500-1000 U/ml)than low inducing concentration groups(100-400 U/ml).The reasonable concentration was 500 U/ml.The NK killing rate was lower in high inducing concentration groups(500-1000 U/ml)(P0.01).Conclusion The human hepatocarcinomal cells expressing HLA-E,induced by IFN-γ,might escape from NK immunosurveillance thorough pathway of non classical HLA-Ⅰ(HLA-E)." @default.
- W2376014487 created "2016-06-24" @default.
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- W2376014487 date "2009-01-01" @default.
- W2376014487 modified "2023-09-24" @default.
- W2376014487 title "IFN-γ induced human hepatocarcinomal cells expressing HLA-E gene to escape from NK cytotoxicity" @default.
- W2376014487 hasPublicationYear "2009" @default.
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