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- W2376016762 abstract "Objective To explore the different expression profiles of microRNA in ovarian serous cancer tissue with both chemoresistant and sensitive status,for a better understanding of chemoresistance in the mechanism of chemoresistance in ovarian serous cancer.Methods The expression of microRNA was evaluated by microRNA microarray in the human ovarian carcinoma skov3 cells and paclitaxel resistant skov3-tr30 cells.The differently expressed microRNA was selected for further verification of the selected microRNA in 20 pairs of chemoresistant and sensitive ovarian serous cancer tissues.Results A total of 171 microRNA related to chemoresistant ovarian cancer cells were selected by microarray,in which 69 microRNA(miR-17,miR-19b,miR-92-1,miR-210,miR-1307,etc.)were up-regulated while 102 microRNA(miR-134,miR-34,miR-196b,etc.)were down-regulated in skov3-tr30 cells.miR-17-92 was one of the microRNA which had good correlation with ovarian carcinoma chemoresistance.Chemoresistant ovarian serous cancer expressed obviously higher level of miR-17-92 cluster than the chemosensitive tissue,with a good statistical significance(P0.01).In ovarian serous cancer and the chemoresistance of ovarian serous cancer,there was no obvious correlation between expression of miR-17-92 cluster and factors of biological behaviors before and after menopause,surgical pathologic stage,histological grade,lymph node dissection,and lymph node metastasis(P0.05).Conclusion microRNA microarray is a valid method to screen differentially expressed microRNA.miR-17-92 could be a causal factor to the chemoresistance of ovarian serous cancer.This study provides a theoretical basis for the research of ovarian serous cancer chemoresistance." @default.
- W2376016762 created "2016-06-24" @default.
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- W2376016762 date "2013-01-01" @default.
- W2376016762 modified "2023-09-24" @default.
- W2376016762 title "Screening of Differentially Expressed microRNA in Chemoresistant and Sensitive Ovarian Cancer Cells and the Identification of the Tissues" @default.
- W2376016762 hasPublicationYear "2013" @default.
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