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- W2376017551 abstract "Objective To explore the cardioprotective effects of genistein(GST) on myocardial ischemia/reperfusion(I/R) injury in male rabbits,and to discuss its possible mechanisms.Methods The left anterior descending coronary artery was fully occluded in anesthetized open-chest rabbits,and then they were subjected to 40 min myocardial ischemia followed by reperfusion for 2 h.The rabbits were randomly assigned to 4 groups: sham group(the coronary artery was not occluded);I/R group;GST+I/R group(GST was administered intravenously 5 min prior to coronary occlusion);Vehicle +I/R group(dimethylsulfoxide was administered intravenously 5 min prior to coronary occlusion).The activities of lactate dehydrogenase(LDH) and serum creatine kinase(CK) were assayed throughout the experiment.Infarct size was assessed by TTC staining,and apoptosis cardiomyocytes were detected by TUNEL staining at the end of reperfusion.Results Rabbits treated with GST showed significant reduction of infarct size and decrease of apoptotic index and the activities of LDH and CK(versus I/R group or Vehicle +I/R group,P0.01,all).No differences were observed between I/R group and Vehicle+I/R group.Conclusion GST administered before ischemia exerts significant effects of protecting myocardium against I/R injury,which may contribute to its reduced myocardium necrosis and anti-apoptotic roles." @default.
- W2376017551 created "2016-06-24" @default.
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- W2376017551 date "2008-01-01" @default.
- W2376017551 modified "2023-09-22" @default.
- W2376017551 title "Protective effect of genistein on myocardial ischemia/reperfusion injury of rabbits" @default.
- W2376017551 hasPublicationYear "2008" @default.
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