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- W2376035696 abstract "OBJECTIVE To analyze the distribution and mutation of resistant genotype of Hepatitis B virus in Uyghur and Han population in Xinjiang area.METHODS A total of 927 serum samples were collected from Uyghur and Chinese CHB patients with HBV DNA positive and resistance mutation and genotype analysis of rtL180M,rtM204I,rtM204V,rtA181T,rtA181V and rtN236T were done in all the samples by gene chips.RESULTS The mutation rate of HBV resistance in Uyghur and Chinese were 53.26% and 59.28%,the difference was not statistically significant(χ2 =1.2389,P0.05);In the four mutant resistant sites,the differences between the two nations were not statistically significant in rtL180M,rtM204I/V and rtN236T mutations(P0.05);The rate of rtA181T/V mutations in Uyghur and Chinese were 13.04% and 31.74%,and the difference was statistically significant(χ2=13.8204,P0.05).CONCLUSION There is no difference between Uyghur and Chinese in hepatitis B virus resistance mutation.In the 6 kinds of mutations,only rtA181T/V is different between the two populations,and Uyghur is lower than Chinese.The rtL180M,rtM204I/V and rtN236 are still the common HBV resistance mutations in Uyghur." @default.
- W2376035696 created "2016-06-24" @default.
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- W2376035696 date "2012-01-01" @default.
- W2376035696 modified "2023-09-27" @default.
- W2376035696 title "Research on distribution and mutation of resistant genotypes in hepatitis B virus in Uyghur and Han population in Xinjiang" @default.
- W2376035696 hasPublicationYear "2012" @default.
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