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- W2376046871 abstract "Objective To explore the influences of GABA ergic neurotransmitter and GABAB receptors on the excitatory changes from the vestibulocochlear nerve afferent brainstem pathway evoked by electro-stimulation. Methods Brainstem slices were prepared using ddyddy mice of postnatal 0-5th days. The brainstem slices were stained with voltage-sensitive dye NK3041. The cut end of the vestibulocochlear nerve(nⅧ) was stimulated by an electrical pulse through a tungsten electrode; a16 × 16 pixels silicon photodiode array was used to record the absorbency changes of voltage-sensitive dye induced by depolarization of membrane potentials from auditory brainstem slices. On the neuronal activities, the influences of GABA and an antagonist against GABAB receptors, 2-hydroxysaclofen(saclofen) were observed. The experimental data were analyzed by ARGUS-50PDA software. Results The spatio-temporal distribution of excitatory propagations from the vestibulocochlear nerve to cochlear nucleus and vestibular nucleus was recorded with a multiple-sites optical recording system. The neuronal avtivities were displayed with changes of electrical potentials or colors. The electrical signals consisted of a fast spike-like response and a following slow response from each pixel. Inhibitory neurotransmitter GABA could decrease the both amplitudes of fast spike-like responses and following slow responses, whereas the saclofen reversed the effects of GABA partially. As the concentration increased(50μmolL ～ 100μmolL), saclofen induced a reinforced fast spike-like response and a after-hyperpolarization response which followed the fast spike-like response in the cochlear nucleus and cerebellum. Conclusion The excitatory neuronal avtivities were recorded along the brainstem afferent pathway evoked by electro-stimulation to the cut end of the vestibulocochlear nerve. GABA and saclofen,an antagonist against GABAB receptors modulated the evoked neuronal activities. The present experiment suggests that GABA and saclofen play important physiological roles in the auditory afferent pathway and cerebellum." @default.
- W2376046871 created "2016-06-24" @default.
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- W2376046871 date "2007-01-01" @default.
- W2376046871 modified "2023-09-24" @default.
- W2376046871 title "Influences of GABA_B receptors on the neuronal activities of afferent impulses along the vestibulocochlear nerve brainstem pathway" @default.
- W2376046871 hasPublicationYear "2007" @default.
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