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- W2376066413 abstract "Amphotericin B(AmB)-loaded poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) microspheres were prepared by phase separation.The effect of the solvent/nonsolvent system,the composition of copolymer and the dosage of the Tween80 on the size,the entrapment efficiency and the release behavior of the AmB loaded microspheres were investigated.The morphology of microspheres was characterized by atomic force microscopy(AFM) and transmission electron microscopy(TEM) respectively.The average particle size and size distribution were measured by laser light scattering technique.The entrapment ratio of AmB by microspheres was measured by UV spectrophotometer.It was found the microspheres size increased with the increase of LA/PEG weight ratio and the molecular weight of PEG segment in the PLA-PEG.The entrapment efficiency of AmB in PLA-PEG microspheres became higher and release rate became slower with the increase of LA/PEG ratio and addition of Tween-80." @default.
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- W2376066413 date "2007-01-01" @default.
- W2376066413 modified "2023-09-22" @default.
- W2376066413 title "Preparation and in vitro Release Behavior of Amphotericin B Loaded PLA-PEG Microspheres" @default.
- W2376066413 hasPublicationYear "2007" @default.
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