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- W2376068644 abstract "Objective:To study the role and mechanism of c myc ASODNS on cell expression of surface antigen of the tumor cells and susceptibility of target cells to immune cells attack.Methods:c myc mRNA was examined by RT PCR.MTT assay was usd to explore the effects of c myc ASODNS on PG cell sentisentity to lysis by CD 3AK effector cells.The expression of HLA ABC,ICAM 1,c myc protein was examined by flow cytometry.Results:When PG cells were treated with ASODNS(1 μmol/L) there was a markably reduction of expression of c myc protein.Expression ratio of HLA ABC and ICAM 1 surface antigen expression ratio of PG cells were enhanced from 68.44%,38.44% to 83.16% and 42.09% respectively( P 0.01).After exposure of PG cells to c myc ASODNS,the susceptitility of PG cells to lysis by CD 3AK was enhanced from 40.0%,65.0%,74.0% to 52.0%,74.0% and 91.0%( P 0.01) at an different effector:target ratio respectively.Conclusion:c myc ASODNS can block and inhibit expression of c myc mRNA and protein,enhance expression of adhesion molecules ICAM 1 and HLA ABC which agument sentisentity of PG cells to lysis by CD 3AK effector cells." @default.
- W2376068644 created "2016-06-24" @default.
- W2376068644 creator A5084518776 @default.
- W2376068644 date "2003-01-01" @default.
- W2376068644 modified "2023-09-25" @default.
- W2376068644 title "Effects of c-myc antisense oligodeoxyribonucleotides(ASODNS) on the expression of surface antigen of the tumor cells and susceptibility of target cells to CD_3AK attack" @default.
- W2376068644 hasPublicationYear "2003" @default.
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