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- W2376070529 abstract "Objective:The study aimed to explore the relationship between serum vitamin D and inflammatory factors and sex hormones of late pregnancy women with gestational diabetes mellitus(GDM).Methods: 25 women diagnosed with GDM were selected as GDM group and 25ealthy pregnant women as control group.The serum 25-(OH)D,Lipopolysaccharide(LPS),Tumor Necrosis Factor-α(TNF-α),Interleukin-6(IL-6),estrogen,androgen,Fasting glucose(FBG),Fasting insulin(FINS) were measured in the period around 36~40 gestational weeks.Results: The level of serum 25-(OH)D in GDM group(26.47±8.6)ng/L is significantly lower than control group(35.0±14.9)ng/L(z=-2.0,P=0.045).The levels of serum LPS,TNF-α,estrogen and IR in GDM group were significantly higher than control group(z=-2.25,P=0.024;z=-2.843,P=0.004;t=-2.167,P=0.035;t=-2.063,P=0.045).The serum 25-(OH)D3 median was negatively correlated to LPS,Homa IR and TNF-α(r=-0.379,P=0.007;r=-0.347,P=0.014;r=-0.2843,P=0.004),but not IL-6 and androgen.Conclusions: Vitamin D may participate in the inhibition of chronic immune inflammatory reaction in women with GDM,accordingly it may reduce the IR.Excessive estrogen also may be risk factors for gestational diabetes." @default.
- W2376070529 created "2016-06-24" @default.
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- W2376070529 date "2013-01-01" @default.
- W2376070529 modified "2023-09-24" @default.
- W2376070529 title "Analysis about vitamin D and inflammatory factors,and sex hormones in Gestational diabetes." @default.
- W2376070529 hasPublicationYear "2013" @default.
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