Matches in SemOpenAlex for { <https://semopenalex.org/work/W2376070566> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2376070566 abstract "Objective Heparanase can specifically cleave carbohydrate chains of heparan sulphate proteoglycans, which is an important component of the extracellular matrix. This study was designed to investigate the expression of heparanase in patients with colorectal cancer, and to analyze its relationships with progression of the cancer and clinical prognosis. Methods Samples were collected from 36 patients with colorectal cancers from 2003 to 2004 in Peking Union Medical College Hospital, and were embeded by Paraffin and fresh-frozened. The expression of heparanase mRNA and its protein were measured by RT-PCR and immunohistochemistry. The relationships between these expressions and the clinicopathologic information (tumor invasion, tumor differentiation, lymph node involvement, accompanying with colorectal adenoma and 2-year survival) were also evaluated. Results The expressions of heparanase mRNA in colorectal cancer (19/31, 61.3%) were significantly higher than those in normal colorectal tissues (6.5%). The overexpressions in normal tissues were positively correlated to the incidence of adenoma in patients with colorectal cancer (r=0.352, P=0.024). The result of immunohistochemistry also showed that heparanase mainly expressed in the vascular endothelium within cancer tissues and the peripheral invased region outside cancer tissues. The 2-year disease-free-survival in patients with negative heparanase expression (88.9%) was higher than that with positive heparanase expression (50.0%), but there was no significant difference (P=0.078). Conclusion Heparanase overexpressed in colorectal cancer tissues, and thus it may take a role as an indicator for the formation and prognosis of colorectal cancer." @default.
- W2376070566 created "2016-06-24" @default.
- W2376070566 creator A5076242635 @default.
- W2376070566 date "2007-01-01" @default.
- W2376070566 modified "2023-09-23" @default.
- W2376070566 title "Heparanase Expression in Colorectal Cancer and Its Relationship with Clinical Prognosis" @default.
- W2376070566 hasPublicationYear "2007" @default.
- W2376070566 type Work @default.
- W2376070566 sameAs 2376070566 @default.
- W2376070566 citedByCount "0" @default.
- W2376070566 crossrefType "journal-article" @default.
- W2376070566 hasAuthorship W2376070566A5076242635 @default.
- W2376070566 hasConcept C111669997 @default.
- W2376070566 hasConcept C121608353 @default.
- W2376070566 hasConcept C126322002 @default.
- W2376070566 hasConcept C142724271 @default.
- W2376070566 hasConcept C143998085 @default.
- W2376070566 hasConcept C204232928 @default.
- W2376070566 hasConcept C2776861080 @default.
- W2376070566 hasConcept C2777478136 @default.
- W2376070566 hasConcept C2779013556 @default.
- W2376070566 hasConcept C502942594 @default.
- W2376070566 hasConcept C526805850 @default.
- W2376070566 hasConcept C71924100 @default.
- W2376070566 hasConceptScore W2376070566C111669997 @default.
- W2376070566 hasConceptScore W2376070566C121608353 @default.
- W2376070566 hasConceptScore W2376070566C126322002 @default.
- W2376070566 hasConceptScore W2376070566C142724271 @default.
- W2376070566 hasConceptScore W2376070566C143998085 @default.
- W2376070566 hasConceptScore W2376070566C204232928 @default.
- W2376070566 hasConceptScore W2376070566C2776861080 @default.
- W2376070566 hasConceptScore W2376070566C2777478136 @default.
- W2376070566 hasConceptScore W2376070566C2779013556 @default.
- W2376070566 hasConceptScore W2376070566C502942594 @default.
- W2376070566 hasConceptScore W2376070566C526805850 @default.
- W2376070566 hasConceptScore W2376070566C71924100 @default.
- W2376070566 hasLocation W23760705661 @default.
- W2376070566 hasOpenAccess W2376070566 @default.
- W2376070566 hasPrimaryLocation W23760705661 @default.
- W2376070566 hasRelatedWork W1983409725 @default.
- W2376070566 hasRelatedWork W2049811381 @default.
- W2376070566 hasRelatedWork W2060064646 @default.
- W2376070566 hasRelatedWork W2103137023 @default.
- W2376070566 hasRelatedWork W2350809075 @default.
- W2376070566 hasRelatedWork W2356262545 @default.
- W2376070566 hasRelatedWork W2356462932 @default.
- W2376070566 hasRelatedWork W2359859634 @default.
- W2376070566 hasRelatedWork W2360176211 @default.
- W2376070566 hasRelatedWork W2361884320 @default.
- W2376070566 hasRelatedWork W2371019835 @default.
- W2376070566 hasRelatedWork W2373141530 @default.
- W2376070566 hasRelatedWork W2374678125 @default.
- W2376070566 hasRelatedWork W2376362945 @default.
- W2376070566 hasRelatedWork W2387570871 @default.
- W2376070566 hasRelatedWork W2387816016 @default.
- W2376070566 hasRelatedWork W2394269629 @default.
- W2376070566 hasRelatedWork W3141710941 @default.
- W2376070566 hasRelatedWork W3146647637 @default.
- W2376070566 hasRelatedWork W3151369627 @default.
- W2376070566 isParatext "false" @default.
- W2376070566 isRetracted "false" @default.
- W2376070566 magId "2376070566" @default.
- W2376070566 workType "article" @default.