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- W2376070931 abstract "Objective: To investigate the influence of siRNA(short interfering RNA) to the expression of PPARγ,to understand the change of endothelin-(ET-1) gene expression when PPARγ diversified,and to explore the role of PPARγ in the mechanism of atherosclerosis.Methods: The HUVEC was intervened with siRNA Expression Cassette segments in vitro.After 24 hours,the mRNA of PPARγ and ET-1 were detected with RT-PCR and quantitative real-time PCR,and the protein of PPARγ was measured with Western blot.Results: siRNA Expression Cassette 1(1 326) down-regulated the mRNA and protein espression of PPARγ and up-regulated ET-1 gene mRNA expression at the same time.A correlation was found between the two genes(r=0.995,P=0.042).Conclusion: siRNA Expression Cassette 1(1 326) can cause an inhibition of PPARγ expression which leads to an increase of ET-1 expression.Therefore,both of PPARγ and ET-1 play a key role in formation of the atherosclerosis." @default.
- W2376070931 created "2016-06-24" @default.
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- W2376070931 date "2007-01-01" @default.
- W2376070931 modified "2023-09-25" @default.
- W2376070931 title "Effects of siRNA Segments on the Expression of Peroxisome Proliferator-activated Receptor Gamma and Endothelin-1" @default.
- W2376070931 hasPublicationYear "2007" @default.
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